I2X is a reactive and event-driven framework that simplifies and automates real-time data integration and interoperability. This platform streamlines the creation of customizable integration tasks connecting heterogeneous data sources with any kind of services. Integration is poll-based, with intelligent agents monitoring data sources, or push-based, where the platform waits for data submission by external resources. I2X delivers data to services through a comprehensive template engine, where the platform maps data from the original data source to the destination resources. I2X is an open-source framework available online at https://bioinformatics.ua.pt/i2x/.