GReEn

GReEn
GReEn: a tool for efficient compression of genome resequencing data.

About
Research in the genomic sciences is confronted with the volume of sequencing and resequencing data increasing at a higher pace than that of data storage and communication resources, shifting a significant part of research budgets from the sequencing component of a project to the computational one. Hence, being able to efficiently store sequencing and resequencing data is a problem of paramount importance.
We describe GReEn (Genome Resequencing Encoding), a tool for compressing genome resequencing data using a reference genome sequence. It overcomes some drawbacks of the recently proposed tool GRS, namely, the possibility of compressing sequences that cannot be handled by GRS, faster running times and compression gains of over 100-fold for some sequences.
GReEn is available for non-commercial use. For other uses, please send an email to ap@ua.pt.
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Citation
Armando J. Pinho, Diogo Pratas, Sara P. Garcia. (2012). GReEn: a tool for efficient compression of genome resequencing data. Nucleic acids research, 40(4), e27-e27.
DOI: 10.1093/nar/gkr1124