EU-ADR specific data types v2.6.2 This is the main document element. It must be the root of the XML file. This element must contain at least one relationship element and may include at most one score element. The creator element contains a description for the triggered service and the execution status code (error handling). Score is used to present the calculated Relative Risk for the Drug/Event pair being analysed. In addition, other classification values can be added. These are the extra calculated values. Relation should have one or more sources of information that support or describe this relationship. The strength value for this relationship. Interaction is the relation between two elements from different sets. In the case of an element from the set {drugs} and an element from the set {targets}, interaction refers to the magnitude and type of their binding or functional affinity. the magnitude of the interaction between an element "drug" and an element "target". Values are given as -log(10^-Interaction) in mol units (i.e., a value of 6 corresponds to micromolar affinity; a value of 9 to nanomolar affinity). (Changed to string by Anna's request). The ID of this concept. The date and time this concept was created. Status is used to identify the service response status.Code list:

• 10 - Correct service execution
• 21 - Invalid ATC Drug code: invalid ATC format (Ex. 'HOLA')
• 22 - Unknown ATC Drug code: valid ATC code but not available in service database
• 23 - Invalid Event code: invalid Event format (Ex. '12345')
• 24 - Unknown Event code: valid Event code but not available in service database
• 25 - No match for Drug-Event pair (Signal (Drug-Event pair) does not exist in database)
• 26 - No mapping from ATC to SMILE format available in service database
• 27 - No annotation to proteins (UniProt) for translated (SMILE) drug code
• 28 - No annotation to proteins (UniProt) for provided Event code
• 31 - No evidence found for Drug-Event pair: no service results for Signal (Drug-Event pair)
• 32 - Evidence not relevant for Drug-Event pair: results were found, but are not important for the expected service output (Ex. UB2 with 1 or 2 evidences)
• 41 - Unable to connect to database (service error)
• 42 - Service server exception (service error)
• 43 - Internal service error (miscellaneous internal service or server errors)

The calculated score for the relative risk. The type of interaction between an element "source" and an element "target".

• pKi
• pKd
• pIC50
• pEC50

The level of evidence.

• FACTUAL
• OBSERVATIONAL
• TEXT_MINING
• CO_OCCURRENCE_SENTENCE
• CO_OCCURRENCE_ABSTRACT
• SIMILARITY

The type of relation describes what is the interaction between concepts under consideration.

• INHIBITS
• CAUSES
• AFFECTS
• BINDS
• POSITIVELY_RELATED
• NEGATIVELY_RELATED